Investigación

Áreas de investigación

Epidemiología de patógenos respiratorios
RSV
COVID 19
Influenza
Rinovirus
Metapneumovirus
Mecanismos moleculares de enfermedades
Mortalidad INFANTil
MITS
Economía de la Salud
Asma
Displasia broncopulmonar
Dengue
Vacunas

Proyectos con financiamiento

En desarrollo: 1) Fundación Bunge y Born (2023). Investigador Principal: Mauricio Caballero. Título del proyecto: Identificación de determinantes sociosanitarios en la carga de enfermedad grave, crítica y mortal debido a infecciones del tracto respiratorio inferior en pacientes menores de 5 años en el área metropolitana de Buenos Aires.
2) MSD (2023-2025). Investigador Principal: Pablo Irusta, Georgetown University. Sub-financiado a Mauricio Caballero. Carga económica de la enfermedad grave por RSV en lactantes y niños pequeños de Argentina, Brasil y Colombia.
3) The Bill and Melinda Gates Foundation (2022-2024). Investigador Principal: Mauricio Caballero desde la Fundación INFANT. Dinámicas de la infección por RSV en el contexto de la pandemia de COVID19 en Argentina.
Pasados 1) PATH - The Bill and Melinda Gates Foundation (2022-2023). Otorgado a Fundación INFANT. Co Investigador principal: Mauricio Caballero. Carga económica por RSV en lactantes de Argentina.

Producción científica

Trabajos publicados por el grupo

1. Julia Dvorkin, Clint Pecenka, Emiliano Sosa, Andrea Sancilio, Karina Dueñas, Andrea Rodriguez, Carlos Rojas-Roque, Patricia B. Carruitero, Ranju Baral, Elisabeth Vodicka, Fernando P. Polack, Romina Libster, Mauricio T. Caballero. Assessing the Long-Term Economic Impact of Wheezing Episodes After Severe RSV Disease in Children from Argentina: A Cost of Illness Analysis. medRxiv 2024.03.18.24304483; doi: https://doi.org/10.1101/2024.03.18.24304483
2. Guiñazú G, Dvorkin J, Mahmud S, et al., 2024. Evaluation of the Impact and Cost-Effectiveness of Respiratory Syncytial Virus Prevention Strategies for INFANTs in Argentina. Published online March 14. DOI:10.2139/ssrn.4754920.
3. Dvorkin J., Sosa E., Vodicka E., Baral R., Sancilio A, Dueñas K, Rodriguez A., Rojas-Roque C., Carruitero PB., Polack FP., Pecenka C., Libster R., Caballero MT. Cost of illness due to Respiratory Syncytial Virus Acute Lower Respiratory Tract Infection Among Infants Hospitalized in Argentina. BMC Public Health https://doi.org/10.21203/rs.3.rs-3386023/v1
4. Cho, H. Y., Wang, X., Campbell, M. R., Panduri, V., Coviello, S., Caballero, M. T., Bennett, B. D., Kleeberger, S. R., Polack, F. P., Ofman, G., & Bell, D. A. (2023). Prospective epigenome and transcriptome analyses of cord and peripheral blood from preterm infants at risk of bronchopulmonary dysplasia. Scientific reports, 13(1), 12262. https://doi.org/10.1038/s41598-023-39313-0
5. Dvorkin, J., De Luca, J., Alvarez-Paggi, D., & Caballero, M. T. (2023). Responding to Higher-Than-Expected Infant Mortality Rates from Respiratory Syncytial Virus (RSV): Improving Treatment and Reporting Strategies. Infection and drug resistance, 16, 595–605. https://doi.org/10.2147/IDR.S373584
6. Löwensteyn, Y. N., Willemsen, J. E., Mazur, N. I., Scheltema, N. M., van Haastregt, N. C. J., Buuren, A. A. A. T., van Roessel, I., Scheepmaker, D., Nair, H., van de Ven, P. M., Bont, L. J., & on behalf of the RSV GOLD Study Group (2023). Nosocomial RSV-related In-hospital Mortality in Children <5 Years: A Global Case Series. The Pediatric infectious disease journal, 42(1), 1–7. https://doi.org/10.1097/INF.0000000000003747
7. Li Y, Wang X, Blau DM, et al. Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in children younger than 5 years in 2019: a systematic analysis. Lancet. 2022;S0140-6736(22)00478-0. doi:10.1016/S0140-6736(22)00478-0
8. Wang X, Cho HY, Campbell MR, et al. Epigenome-wide association study of bronchopulmonary dysplasia in preterm infants: results from the discovery-BPD program. Clin Epigenetics. 2022;14(1):57.
9. Esteban I, Bergero G, Alves C, et al. Asymptomatic COVID-19 in the elderly: dementia and viral clearance as risk factors for disease progression. Gates Open Res. 2022;5:143. Published 2022 Apr 4. doi:10.12688/gatesopenres.13357.2
10. Caballero MT, et al. Uncovering Causes of Childhood Death Using the Minimally Invasive Autopsy at the Community Level in an Urban Vulnerable Setting of Argentina: A Population-Based Study. Clin Infect Dis. 2021;73(Suppl_5):S435-S441
11. Larcade R,  et al. Maternal-Fetal Immunologic Response to SARS-CoV-2 Infection in a Symptomatic Vulnerable Population: A Prospective Cohort. J Infect Dis. 2022;225(5):800-809.
12. Polack FP, et al. Fatal enhanced respiratory syncytial virus disease in toddlers. Sci Transl Med. 2021;13(616):eabj7843.
13. Mazur NI, Löwensteyn YN, Willemsen JE, Gill CJ, Forman L, Mwananyanda LM, Blau DM, Breiman RF, Madhi SA, Mahtab S, Gurley ES, El Arifeen S, Assefa N, Scott JAG, Onyango D, Tippet Barr BA, Kotloff KL, Sow SO, Mandomando I, Ogbuanu I, Jambai A, Bassat Q; CHAMPS Network the RSV GOLD Study Group, Caballero MT, Polack FP, Omer S, Kazi AM, Simões EAF, Satav A, Bont LJ. Global Respiratory Syncytial Virus-Related Infant Community Deaths. Clin Infect Dis. 2021 Sep 2;73(Supplement_3):S229-S237. doi: 10.1093/cid/ciab528. PMID: 34472576; PMCID: PMC8411255.
14. Caballero MT, Satav A, Gill CJ, Omer SB, Pieciak RC, Kazi AM, Simões EA, Polack FP. Challenges of Assessing Community Mortality Due to Respiratory Viruses in Children Aged Less Than 5 Years. Clin Infect Dis. 2021 Sep 2;73(Supplement_3):S248-S254. doi: 10.1093/cid/ciab487. PMID: 34472573; PMCID: PMC8411250.
15. Caballero MT, Bianchi AM, Grigaites SD, De la Iglesia Niveyro PX, Nuño A, Valle S, Afarian G, Esperante SA, Ferretti AJP, Jares Baglivo S, De Luca J, Alvarez-Paggi D, Diamanti A, Bassat Q, Polack FP; RSV mortality network. Community Mortality Due to Respiratory Syncytial Virus in Argentina: Population-based Surveillance Study. Clin Infect Dis. 2021 Sep 2;73(Supplement_3):S210-S217. doi: 10.1093/cid/ciab497. PMID: 34472572; PMCID: PMC8411253.
16. Libster R, Pérez Marc G, Wappner D, Coviello S, Bianchi A, Braem V, Esteban I, Caballero MT et al. Early High-Titer Plasma Therapy to Prevent Severe Covid-19 in Older Adults. N Engl J Med. 2021 Feb 18;384(7):610-618. doi: 10.1056/NEJMoa2033700. Epub 2021 Jan 6. PMID: 33406353; PMCID: PMC7793608.
17. Ofman G, Pradarelli B, Caballero MT, Bianchi A, Grimaldi LA, Sancilio A, Duenas K, Rodriguez A, Ferrero F, Ferretti A, Coviello S, Ferolla FM, Acosta PL, Bergel E, Libster R, Polack FP. Respiratory Failure and Death in Vulnerable Premature Children With Lower Respiratory Tract Illness. J Infect Dis. 2020 Sep 1;222(7):1129-1137. doi: 10.1093/infdis/jiaa046. PMID: 32006428; PMCID: PMC7459133.
18. Libster R, Esteban I, Bianchi A, Alva Grimaldi L, Dueñas K, Sancillo A, Rodriguez A, Ferrero F, Stein K, Acosta PL, Ferolla FM, Bergel E, Caballero MT, Polack FP; INFANT Respiratory Network. Role for Maternal Asthma in Severe Human Metapneumovirus Lung Disease Susceptibility in Children. J Infect Dis. 2021 Jun 15;223(12):2072-2079. doi: 10.1093/infdis/jiaa019. PMID: 31965186; PMCID: PMC7107446.
19. Menendez D, Snipe J, Marzec J, Innes CL, Polack FP, Caballero MT, Schurman SH, Kleeberger SR, Resnick MA. p53-responsive TLR8 SNP enhances human innate immune response to respiratory syncytial virus. J Clin Invest. 2019 Nov 1;129(11):4875-4884. doi: 10.1172/JCI128626. PMID: 31430261; PMCID: PMC6819090.
20. Ofman G, Caballero MT, Alvarez Paggi D, Marzec J, Nowogrodzki F, Cho HY, Sorgetti M, Colantonio G, Bianchi A, Prudent LM, Vain N, Mariani G, Digregorio J, Turconi EL, Osio C, Galletti F, Quiros M, Brum A, Lopez Garcia S, Garcia S, Bell D, Jones MH, Tipple TE, Kleeberger SR, Polack FP. The discovery BPD (D-BPD) program: study protocol of a prospective translational multicenter collaborative study to investigate determinants of chronic lung disease in very low birth weight infants. BMC Pediatr. 2019 Jul 6;19(1):227. doi: 10.1186/s12887-019-1610-8. PMID: 31279333; PMCID: PMC6612113.
21. Caballero MT, Bianchi AM, Nuño A, Ferretti AJP, Polack LM, Remondino I, Rodriguez MG, Orizzonte L, Vallone F, Bergel E, Polack FP. Mortality Associated With Acute Respiratory Infections Among Children at Home. J Infect Dis. 2019 Jan 9;219(3):358-364. doi: 10.1093/infdis/jiy517. PMID: 30165655; PMCID: PMC6325348.
22. Rajan D, O'Keefe EL, Travers C, McCracken C, Geoghegan S, Caballero MT, Acosta PL, Polack F, Anderson LJ. MUC5AC Levels Associated With Respiratory Syncytial Virus Disease Severity. Clin Infect Dis. 2018 Oct 15;67(9):1441-1444. doi: 10.1093/cid/ciy340. PMID: 29878077.
23. Caballero MT, et al. Interleukin-13 associates with life-threatening rhinovirus infections in infants and young children. Pediatr Pulmonol. 2018 Jun;53(6):787-795. doi: 10.1002/ppul.23998. Epub 2018 Apr 17. PMID: 29665312.
24. High M, Cho HY, Marzec J, Wiltshire T, Verhein KC, Caballero MT, et al. Determinants of host susceptibility to murine respiratory syncytial virus (RSV) disease identify a role for the innate immunity scavenger receptor MARCO gene in human infants. EBioMedicine. 2016 Sep;11:73-84. doi: 10.1016/j.ebiom.2016.08.011. Epub 2016 Aug 6.
25. Acosta PL, Caballero MT, Polack FP.  Brief History and Characterization of Enhanced Respiratory Syncytial Virus Disease. Clin Vaccine Immunol. 2015 Dec 16;23(3):189-95. doi: 10.1128/CVI.00609-15. Review.
26. Geoghegan S, Erviti A, Caballero MT, et al. Mortality due to Respiratory Syncytial Virus. Burden and Risk Factors. Am J Respir Crit Care Med. 2017 Jan 1;195(1):96-103. doi: 10.1164/rccm.201603-0658OC.
27. Caballero MT, et al. TLR4 genotype and environmental LPS mediate RSV bronchiolitis through Th2 polarization. J Clin Invest. 2015 Feb;125(2):571-82. doi: 10.1172/JCI75183. Epub 2015 Jan 2.

Conferencias científicas
2019         Título: “RSV mortality study in Argentina” RSV Vaccines for the World 2019 RESVINET conference. Accra, Ghana.
2019         Título: “Neonatal mortality surveillance based on MITS” MITS Surveillance Alliance. Grant Awardee talk. Seattle, USA.
2019         Título: “Mortalidad comunitaria por virus sincicial respiratorio” I Jornadas Internacionales sobre Infecciones Respiratorias y Vacunas. Tucumán, Argentina.
2020         Título: “Community mortality due to RSV in low-income settings of Buenos Aires, Argentina”. Bill and Melinda Gates Foundation – RSV disease burden convening. Virtual.
2021         Título: “Community mortality due to RSV in Buenos Aires Argentina”. MITS Surveillance Alliance 2020 Virtual Annual Meeting.
2021         Título: “La muerte que llega demasiado temprano en hogares vulnerables del conurbano bonaerense”. XXXII Congreso Científico Argentino de Estudiantes de Medicina. Buenos Aires, Argentina.
2021         Título: “Cause of death based on MITS approach”. MITS Alliance Cause of Death TWG meeting. Virtual.
2021         Título: “COVID 19 mortality in adults by MITS-Argentina”. MITS Incentive Awardees Results and Lessons Learned Webinar.
2021         Título: “MITS NeoSur: Neonatal mortality surveillance program in Buenos Aires: Preliminary results”. MITS Incentive Awardees Results and Lessons Learned Webinar.
2021         Título: “Abordajes transdisciplinarios multi-nivel en investigación traslacional: desde las ciencias básicas hacia la medicina clínica”. Instituto de Investigaciones Biotecnológicas Universidad de San Martín. Interinstitutional lectures.
2021         Título: “Virus Sincicial Respiratorio en lactantes: un enfoque traslacional”. Instituto de Investigaciones en Microbiología y Parasitología Médica (IMPaM, UBA-CONICET).
2021         Título: “Cause of death based on MITS approach”. MITS Incentive Awardees Results and Lessons Learned Webinar.
2021         Título: “Unraveling Specific Causes of Under 5 Community Mortality in Argentina by MITS technique”. MITS Alliance Technical Working Group Meetings. Virtual.
2021         Título: “Minimally Invasive Tissue Sampling (MITS)- Accurate cause of death attribution and surveillance in low-resource settings”. MITS Alliance Cause of Death TWG meeting. Virtual.
2021         Título: “Introduction to clinical research in Pediatrics”. Research in pediatrics program. Children Hospital of La Plata, Argentina.
2022         Título: “La muerte que llega demasiado temprano en hogares vulnerables: RSV el enemigo oculto”. XIV Colombian Congress of Pediatric Asthma and Respiratory Medicine. Bogotá, Colombia.
2022         Título: “Es tiempo de decir adiós a lo que llamamos Bronquiolitis”. XIV Colombian Congress of Pediatric Asthma and Respiratory Medicine. Bogotá, Colombia.
2022         Título: “La necesidad de una vacuna contra virus sincicial respiratorio para adultos mayores”. Actividad de educación continua para médicos (CPD) virtual de WebMD Global (Medscape) aprobado por The Faculty of Pharmaceutical Medicine of the Royal Colleges of Physicians of the United Kingdom (FPM). CPD 0.5 Actividad en español. https://www.medscape.org/viewarticle/970071_sidebar5
2022         Título: “La necesidad de una vacuna contra virus sincicial respiratorio para adultos mayores”. Actividad de educación continua para médicos (CPD) virtual de WebMD Global (Medscape) aprobado por The Faculty of Pharmaceutical Medicine of the Royal Colleges of Physicians of the United Kingdom (FPM). CPD 0.5. https://www.medscape.org/viewarticle/968910_sidebar6
2022         Título: “Un camino hacia la medicina personalizada en la bronquiolitis”. CEINBIO Simposio, Montevideo Uruguay.
2022         Mesa Prevención frente a infección por Virus Sincitial Respiratorio Tema Actualización en vacunas contra VSR Jornada Actualización Manejo y seguimiento del bebé con riesgo de enfermedad respiratoria, ALSEPNEO. Virtual Noviembre 2022.
2022         Título: "From the bench to the bedside in clinical research". Reunión Anual de Sociedades de Biociencias SAIC, SAI, SAFIS 2022.
2023         “Minimal Invasive tissue sampling implementation in Argentina”, Primera Reunión Regional De Vacunación Segura de las Américas - PAHO, Bogotá, Colombia
2023         “Mesa Prevención frente a infección por Virus Sincitial Respiratorio Tema Actualización en vacunas contra VSR”. Jornadas Actualización Manejo y seguimiento del bebé con riesgo de enfermedad respiratoria, Asociación Latinoamericana de seguimiento pediatrico y neonatal. Colombia.
2023         “Cause of deaths at community level in Argentina”, 35th European Congress of Pathology, Dublin, Ireland.
2023         “Implementation of MITS in Argentina”, MITS Surveillance Alliance Meeting, Nairobi, Kenya.
2023         “Estrategias preventivas contra VSR", XIII Congreso Argentino de Neumonología Pediátrica y XVII Congreso Latinoamericano de Fibrosis Quistica, Sociedad Latinoamericana de neumonología pediatrica (SOLANEP), Buenos Aires, Argentina.

Trabajos en congresos y reuniones
2019         “Community mortality due to acute respiratory infection”, MITS Surveillance Alliance Meeting, Seattle, USA.
2019         “Community mortality due to acute respiratory infection”, 5th RSV Vaccines for the World, Accra, Ghana.
2019         “Wheezing trajectories after a severe RSV disease: Machine learning approach”, 5th RSV Vaccines for the World, Accra, Ghana.
2021         “An immunoinformatic-based approach to design a population-specific vaccine against RSV”, 6th RSV Vaccines for the World, Virtual.
2021         “Community mortality due to RSV in children under five from low-settings of Buenos Aires”, ISIRV-WHO Virtual Conference.
2022         “Unraveling specific mechanisms of community deaths due to RSV
in Buenos Aires, Argentina”. De la Iglesia P, Ferretti A, Polack FP, Caballero MT. 12th International RSV Symposium, Belfast, Irlanda. Septiembre 2022.
2022         "Role of RSV infection and factors associated with apnea during
acute respiratory tract infections". Julia Dvorkin, Lucas Fleuren, Adrián Ferretti, Romina Libster, Fernando Polack, Mauricio Caballero. 12th International RSV Symposium, Belfast, Irlanda. Septiembre 2022.
2023         "Role of RSV infection and factors associated with apnea during
acute respiratory tract infections". Mauricio Caballero, Adrián Ferretti, Romina Libster, Fernando Polack. 7h RESVINET Conference, Lisboa, Portugal. Febrero 2023.
2023          "AN IMMUNOINFORMATICS-BASED APPROACH TO DESIGN A POPULATION-SPECIFIC VACCINE AGAINST RSV” Goldin Carla, Esperante Sebastian, Mauricio Caballero, Damian Alvarez-Paggi. 7h RESVINET Conference, Lisboa, Portugal. Febrero 2023.

Equipamiento

El Centro cuenta con equipos para diagnóstico clínico-molecular de los siguientes equipos: MagMax Automated DNA Extraction System, StepOne™ Real-Time PCR System, Analizador de inmunoensayo por ELISA DYNEX DSX, MAGPIX® System, Flujo laminar, estufas, freezers y ultrafreezers.